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THE EFFECT by Lucy Prebble

THE EFFECT by Lucy Prebble

Volunteers Tristan and Connie bond during a depression drug trial. As researchers track their dopamine, the pair wonder if their growing connection is genuine affection or merely chemically induced feelings.


Fourth Wall presents Lucy Prebble’s 'The Effect', a sharp, moving drama set in an antidepressant drug trial. Tristan, charming and impulsive, meets Connie, analytical and cautious, and their unexpected attraction intensifies as the medication boosts their dopamine. They question whether their feelings are real or chemically driven. Overseeing them are Dr. James, compassionate yet struggling with her own depression, and Toby, ambitious and convinced of neuroscience’s power.


As professional boundaries blur, the play probes love, mental health, and scientific ethics. Dancing between humor and tension, ‘The Effect’ invites audiences to consider how human connection is shaped by biology and belief.


£6.50 Standard

£6 Concession

£5.50 Performing Arts Members


This event takes place at the Head of Steam, 3 North Road, Durham, DH1 4RZ.


The event begins at 7.30pm, and lasts until approximately 10pm. Doors open 30 minutes before the concert begins.

Book Tickets

Tuesday 9 Dec 202519:30 Book Now